中文名称 | (2'Z,3'E)-6-溴靛玉红-3′-肟 |
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英文名称 | BIO (GSK-3 Inhibitor IX | 6-bromoindirubin-3-oxime | 6-Bromoindirubin-3'-oxime | MLS 2052 | (2'Z,3'E)-6-Bromoindirubin-3'-oxime | 6-BIO | 6BIO |
CAS号 | 667463-62-9 |
分子式 | C16 H10BrN3O2 |
分子量 | 356.17 |
外观 | Brown to red powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively.
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