中文名称 | 替罗非班 | L700462 | MK383 |
---|---|
英文名称 | Tirofiban (Synonyms: L700462; MK383) |
CAS号 | 144494-65-5 |
分子式 | C22H36N2O5S |
分子量 | 440.60 |
外观 | White to off-white powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Tirofiban (L700462) is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area.
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