中文名称 | 托卡朋 |
---|---|
英文名称 | Tolcapone | Ro 40-7592 |
CAS号 | 134308-13-7 |
分子式 | C14H11NO5 |
分子量 | 273.24 |
外观 | Light yellow to yellow powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.
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