托卡朋
Tolcapone | Ro 40-7592
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基本信息
中文名称托卡朋
英文名称 Tolcapone | Ro 40-7592
CAS号134308-13-7
分子式C14H11NO5
分子量273.24
外观Light yellow to yellow powder
储存条件Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.

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