中文名称 | 顺式-4-[(4-氯苯基)磺酰基]-4-(2,5-二氟苯基)环己烷丙酸 |
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英文名称 | MK-0752 |
CAS号 | 471905-41-6 |
分子式 | C21H21ClF2O4S |
分子量 | 442.91 |
MDL | MFCD21608529 |
MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo.
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