中文名称 | 嘧西利 | 米尔西利 |
---|---|
英文名称 | Milciclib | PHA-848125 |
CAS号 | 802539-81-7 |
分子式 | C25H32N8O |
分子量 | 460.57 |
外观 | Light yellow to yellow powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Milciclib is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it's also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy.
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