中文名称 | (R)-2-((6-(苄基氨基)-9-异丙基-9H-嘌呤-2-基)氨基)丁-1-醇 |
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英文名称 | (R)-Roscovitine (Synonyms: Seliciclib; CYC202,细胞周期蛋白B激酶抑制剂;塞利西利) |
CAS号 | 186692-46-6 |
分子式 | C19H26N6O |
分子量 | 354.45 |
MDL | MFCD02266401 |
外观 | White to off-white powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM in cell-free assays. It shows little effect on CDK4/6.
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