中文名称 | 鲁索替尼 | 鲁索利替尼 | 芦可替尼 |
---|---|
英文名称 | Ruxolitinib | INCB018424 | Ruxolitinib Free base | (R)-Ruxolitinib |
CAS号 | 941678-49-5 |
分子式 | C17H18N6 |
分子量 | 306.37 |
外观 | White to light yellow powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.
© 2020-2024 凯立德生物医药技术(上海)有限公司 版权所有
沪ICP备15046197号-3
沪公网安备31011502007856号
Designed by Kuanersoft