CX-5461
CX-5461 | Pidnarulex
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产品库存
3-5days
目录价格
¥288.00
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产品库存
3-5days
目录价格
¥498.00
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产品库存
3-5days
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¥898.00
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产品库存
3-5days
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¥1616.00
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基本信息
中文名称CX-5461
英文名称 CX-5461 | Pidnarulex
CAS号1138549-36-6
分子式C27H27N7O2S
分子量513.61
外观White to yellow powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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产品详情

CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal proteins (RP) from the nucleolus. The RP bind to Mdm2 and liberate p53 to orchestrate apoptosis in cancer cells. CX-5461 demonstrates a favorable preclinical profile, potently and selectively kills cancer cells, demonstrates robust in vivo efficacy in multiple models, and has demonstrated oral bioavailability in multiple species.


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