| 中文名称 | CX-5461 dihydrochloride |
|---|---|
| 英文名称 | CX-5461 dihydrochloride |
| CAS号 | N/A |
| 分子式 | C27H27N7O2S·2HCl |
| 分子量 | 586.54 | 513.62(free) |
| 外观 | Light yellow to yellow powder |
| 储存条件 | 4°C, sealed storage, away from moisture |
CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM).
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