Chemleader Biomedical-Small Molecules 丨Intermediates 丨Drug Impurities

(2S,4S,5S,7S)-5-氨基-N-(3-氨基-2,2-二甲基-3-氧代丙基)-4-羟基-2-异丙基-7-(4-甲氧基-3-( 3-甲氧基丙氧基)苄基)-8-甲基壬酰胺半富马酸盐；阿利克仑半富马酸盐

Aliskiren Hemifumarate (Synonyms: CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate)

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产品编号：CL3027A

CAS No.：173334-58-2

MDLNo：MFCD10566724

分子式：C34H57N3O10

分子量：667.83

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基本信息

中文名称	(2S,4S,5S,7S)-5-氨基-N-(3-氨基-2,2-二甲基-3-氧代丙基)-4-羟基-2-异丙基-7-(4-甲氧基-3-( 3-甲氧基丙氧基)苄基)-8-甲基壬酰胺半富马酸盐；阿利克仑半富马酸盐
英文名称	Aliskiren Hemifumarate (Synonyms: CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate)
CAS号	173334-58-2
分子式	C34H57N3O10
分子量	667.83
MDL	MFCD10566724
外观	White to off-white powder
储存条件	4°C, sealed storage, away from moisture

安全信息

产品详情

Aliskiren hemifumarate (CGP 60536; CGP60536B; SPP 100) is an orally active, selective renin inhibitor with an IC50 of 1.5 nM. It is utilized in research pertaining to hypertension, cardiovascular diseases, and cancer cachexia.As a direct renin inhibitor, aliskiren targets the renin-angiotensin-aldosterone system (RAAS), a key pathway in blood pressure regulation. Its role in hypertension management is significant, offering an alternative to traditional antihypertensive medications. Additionally, aliskiren's potential impact on cardiovascular health and cancer cachexia is under investigation, highlighting its broad research applications.