中文名称 | 6-((3S,4S)-4-甲基-1-(嘧啶-2-基甲基)吡咯烷-3-基)-3-(四氢-2H-吡喃-4-基)咪唑并[1,5-a]吡嗪-8(7H)-酮;IMR-687 |
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英文名称 | Tovinontrine (Synonyms: IMR-687) |
CAS号 | 2062661-53-2 |
分子式 | C21H26N6O2 |
分子量 | 394.47 |
MDL | MFCD34567171 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Tovinontrine (IMR-687) is a highly potent and selective phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. IC50s are 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively.
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