1,4-二氨基-2,3-二氰基-1,4-双(邻氨基苯巯基)丁二烯
U0126 (Synonyms: MEK1/2抑制剂 )
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基本信息
中文名称1,4-二氨基-2,3-二氰基-1,4-双(邻氨基苯巯基)丁二烯
英文名称 U0126 (Synonyms: MEK1/2抑制剂 )
CAS号109511-58-2
分子式C18H16N6S2
分子量380.49
MDLMFCD11046040
外观Off-white to light yellow powder
储存条件Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.
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U-0126, also known as Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile, is a potent and selective MEK inhibitor with IC50 values of 72 nM for MEK1 and 58 nM for MEK2. It effectively inhibits AP-1 transcription activity and is known to block the production of inflammatory cytokines and matrix metalloproteinases. U0126 is an autophagy and mitophagy inhibitor.

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1,4-二氨基-2,3-二氰基-1,4-双(邻氨基苯巯基)丁二烯