中文名称 | 1,4-二氨基-2,3-二氰基-1,4-双(邻氨基苯巯基)丁二烯 |
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英文名称 | U0126 (Synonyms: MEK1/2抑制剂 ) |
CAS号 | 109511-58-2 |
分子式 | C18H16N6S2 |
分子量 | 380.49 |
MDL | MFCD11046040 |
外观 | Off-white to light yellow powder |
储存条件 | Store short-term at 0-4°C or long-term at -20°C in a dry, dark place. |
U-0126, also known as Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile, is a potent and selective MEK inhibitor with IC50 values of 72 nM for MEK1 and 58 nM for MEK2. It effectively inhibits AP-1 transcription activity and is known to block the production of inflammatory cytokines and matrix metalloproteinases. U0126 is an autophagy and mitophagy inhibitor.
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