中文名称 | N-((3S,4S)-3-((6-(2,6-二氯-3,5-二甲氧基苯基)喹唑啉-2-基)氨基)四氢-2H-吡喃-4-基)丙烯酰胺 |
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英文名称 | Fisogatinib (Synonyms: BLU-554) |
CAS号 | 1707289-21-1 |
分子式 | C24H24Cl2N4O4 |
分子量 | 503.38 |
MDL | MFCD30496704 |
外观 | White to light yellow powder |
储存条件 | Store short-term at 0-4°C or long-term at -20°C in a dry, dark place. |
Fisogatinib (BLU-554) is a potent and highly selective oral FGFR4 inhibitor with an IC50 of 5 nM, demonstrating significant anti-tumor activity in HCC models reliant on FGFR4 signaling.Its IC50 values for FGFR1-3 are in the range of 624-2203 nM, highlighting its selectivity over other FGFR isoforms.
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