中文名称 | 7-甲基-2-((7-甲基-[1,2,4]三唑并[1,5-a]吡啶-6-基)氨基)-9-(四氢-2H-吡喃-4-基)-7H-嘌呤-8(9H)-酮 |
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英文名称 | AZD-7648 |
CAS号 | 2230820-11-6 |
分子式 | C18H20N8O2 |
分子量 | 380.40 |
MDL | MFCD32062688 |
外观 | White to yellow powder |
储存条件 | Store short-term at 0-4°C or long-term at -20°C in a dry, dark place. |
AZD-7648 is a potent, orally active, and selective DNA-PK inhibitor with an IC50 of 0.6 nM, demonstrating significant antitumor activity.This compound induces apoptosis and enhances the effects of radiation and chemotherapy, making it a promising therapeutic agent for myeloid leukemias.In addition to its cytotoxic effects, AZD-7648 also triggers cell cycle arrest, further contributing to its antitumor properties.
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