中文名称 | 2-(1-(2-((3R,5S)-1-(3-乙酰氧基-2,2-二甲基丙基)-7-氯-5-(2,3-二甲氧基苯基)-2-氧代-1,2,3,5-四氢苯并[e][1,4]氧氮杂卓-3-基)乙酰基)哌啶-4-基)乙酸 |
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英文名称 | Lapaquistat acetate (Synonyms: TAK-475) |
CAS号 | 189060-13-7 |
分子式 | C33H41ClN2O9 |
分子量 | 645.14 |
MDL | MFCD06407873 |
外观 | White to off-white powder |
储存条件 | Store short-term at 0-4°C or long-term at -20°C in a dry, dark place. |
Lapaquistat acetate, a potent squalene synthase inhibitor, impedes the conversion of farnesyl diphosphate (FPP) to squalene, a key step in cholesterol synthesis. Utilized in treating Mevalonate Kinase Deficiency (MKD), an autosomal recessive disorder, it significantly reduces low-density lipoprotein cholesterol levels. However, its use may be accompanied by liver damage, a known side effect that warrants monitoring.
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