中文名称 | 2-((S)-2-苄基-3-((3R,4R)-4-(3-羟基苯基)-3,4-二甲基哌啶-1-基)丙酰胺基)乙酸二水合物;爱维莫潘 |
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英文名称 | Alvimopan dihydrate (Synonyms: ADL 8-2698 dihydrate; LY 246736 dihydrate) |
CAS号 | 170098-38-1 |
分子式 | C25H36N2O6 |
分子量 | 460.56 |
MDL | MFCD00927248 |
外观 | White to off-white powder |
储存条件 | Store short-term at 0-4°C or long-term at -20°C in a dry, dark place. |
Alvimopan dihydrate (ADL 8-2698 dihydrate) is a selective μ-opioid receptor antagonist with an IC50 of 1.7 nM, exhibiting high potency and oral activity. It demonstrates significant selectivity for the μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively), making it a valuable tool in postoperative ileus research.
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