泰兰斯他汀A
Thailanstatin A
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基本信息
中文名称泰兰斯他汀A
英文名称 Thailanstatin A
CAS号1426953-21-0
分子式C28H41NO9
分子量535.63
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Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC.

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泰兰斯他汀A