I-OMe-Tyrphostin AG 538
I-OMe-Tyrphostin AG 538 (Synonyms: I-OMe-AG 538)
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中文名称I-OMe-Tyrphostin AG 538
英文名称 I-OMe-Tyrphostin AG 538 (Synonyms: I-OMe-AG 538)
CAS号1094048-77-7
分子式C17H12INO5
分子量437.19
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I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 μM.
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