| 中文名称 | 吡啶酮6; 2-(叔丁基)-9-氟-1,6-二氢-7H-苯并[h]咪唑并[4,5-f]异喹啉-7-酮 |
|---|---|
| 英文名称 | Pyridone 6 (Synonyms: JAK Inhibitor I; CMP 6; Janus-Associated Kinase Inhibitor I) |
| CAS号 | 457081-03-7 |
| 分子式 | C18H16FN3O |
| 分子量 | 309.34 |
Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC50s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.
© 2015-2026 凯立德生物医药技术(上海)有限公司 版权所有
沪ICP备15046197号-3
沪公网安备31011502007856号
Designed by Kuanersoft