| 中文名称 | (R)-N-(5-((5-(4-丙烯酰基-3-甲基-1,4-二氮杂环庚烷-1-羰基)-4-甲氧基-2-甲基苯基)硫基)噻唑-2-基)环丙烷甲酰胺;索喹替尼 |
|---|---|
| 英文名称 | Soquelitinib (Synonyms: CPI-818) |
| CAS号 | 2226636-04-8 |
| 分子式 | C25H30N4O4S2 |
| 分子量 | 514.66 |
Soquelitinib (CPI-818) is an orally active and highly selective covalent interleukin-2-inducible kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease, including acute and chronic asthma, pulmonary fibrosis, systemic sclerosis (scleroderma), psoriasis, and acute graft versus host disease with Th2 cytokine product inhibition. Soquelitinib increases tumor infiltration of normal CD8+ cells that possess enhanced T effector function.
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