中文名称 | 达罗托组单抗 |
---|---|
英文名称 | Dalotuzumab (Anti-IGF1R / CD221) |
CAS号 | 1005389-60-5 |
储存条件 | Store at 2 to 8 °C for 1-2 weeks. Store at -20 °C for 12 months. Store at -80 °C for long term storage. Use a manual defrost freezer and avoid repeated freeze-thaw cycles, away from light. |
Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R . Dalotuzumab acts by inhibiting IGF-1 - and IGF-2 -mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo.
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