中文名称 | 艾司妥单抗 |
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英文名称 | Anti-Human IGF1RxHer3 Bispecific Antibody (Istiratumab; MM 141; MM-005) |
CAS号 | 1509928-04-4 |
Istiratumab, a bispecific mAb against IGF-1R and ErbB3, promotes receptor degradation via proteasomes, inhibiting AKT in pancreatic cancer cells and blocking PI3K/MAPK in ovarian cancer. It enhances chemo efficacy, potentiating paclitaxel, cisplatin, and doxorubicin in preclinical studies.
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