中文名称 | 卡度尼利单抗 |
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英文名称 | Anti-Human PD-1xCTLA-4 Bispecific Antibody(Cadonilimab) |
CAS号 | 2394841-59-7 |
储存条件 | -80°C for one-year storage. Avoid repeated freeze-thaw. |
Cadonilimab is a pioneering bispecific antibody targeting PD-1 and CTLA-4,it blocks both PD-1 and CTLA-4 pathways, thereby relieving their corresponding immunosuppressive effects and reversing tumor specific T cell exhaustion. Cadonilimab significantly downregulates Fc-mediated effector functions, including antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement dependent cytotoxicity (CDC). Cadonilimab can be used for research of metastatic cervical cancer, as well as other malignancies such as gastric cancer, GEJ adenocarcinoma and non-small cell lung cancer (NSCLC).
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