西贝瑞单抗
Sibeprenlimab (Synonyms: VIS649)
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中文名称西贝瑞单抗
英文名称 Sibeprenlimab (Synonyms: VIS649)
CAS号2382896-07-1
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Sibeprenlimab (VIS649), a humanized IgG2 monoclonal antibody, neutralizes APRIL, a key factor in IgA nephropathy (IgAN) pathogenesis. It effectively reduces pathogenic IgA and IgM while preserving vaccine responses to SARS-CoV-2 mRNA-based vaccines. Clinical trials demonstrate that sibeprenlimab decreases UPCR and stabilizes GFR, positioning it as a promising treatment for IgAN.

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