中文名称 | 抑肽素 |
---|---|
英文名称 | Pepstatin(Pepstatin A) |
CAS号 | 26305-03-3 |
分子式 | C34 H63N5O9 |
分子量 | 685.89 |
外观 | White to off-white |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Pepstatin A (NSC-272671; NSC272671), a pentapeptide, is a potent and selective aspartic protease inhibitor which also inhibits HIV replication. Pepstatin A was originally isolated from the microbe. For the enzymes hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease, and hemoglobin-acid protease, respectively, its IC50 values are 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM, and 260 nM. At weak acid pH values, pepstatinA, a highly potent renin inhibitor, inhibited both human and porcine renin with IC50 values of 15 μM and 0.32, respectively. For aspartic proteinases like pepsin, cathepsins D and E, pepstatin A effectively inhibits them. Pepstatin A appears to have no harmful effects on HIV-infected cells, but it does block a portion of the intracellular processing of the HIV gag protein in H9 cells that have the virus. By preventing ERK signaling and reducing NFATc1 expression, pepstatin A also prevents osteoclast differentiation.
© 2020-2024 凯立德生物医药技术(上海)有限公司 版权所有
沪ICP备15046197号-3
沪公网安备31011502007856号
Designed by Kuanersoft