抑肽素
Pepstatin(Pepstatin A)
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10 mg 25 mg 50 mg
产品库存
3-5days
目录价格
¥500.00
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产品库存
3-5days
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¥750.00
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产品库存
3-5days
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¥1400.00
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基本信息
中文名称抑肽素
英文名称 Pepstatin(Pepstatin A)
CAS号26305-03-3
分子式C34 H63N5O9
分子量685.89
外观White to off-white
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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产品详情

Pepstatin A (NSC-272671; NSC272671), a pentapeptide, is a potent and selective aspartic protease inhibitor which also inhibits HIV replication. Pepstatin A was originally isolated from the microbe. For the enzymes hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease, and hemoglobin-acid protease, respectively, its IC50 values are 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM, and 260 nM. At weak acid pH values, pepstatinA, a highly potent renin inhibitor, inhibited both human and porcine renin with IC50 values of 15 μM and 0.32, respectively. For aspartic proteinases like pepsin, cathepsins D and E, pepstatin A effectively inhibits them. Pepstatin A appears to have no harmful effects on HIV-infected cells, but it does block a portion of the intracellular processing of the HIV gag protein in H9 cells that have the virus. By preventing ERK signaling and reducing NFATc1 expression, pepstatin A also prevents osteoclast differentiation.

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