中文名称 | N-((S)-1-(((2S,3S)-1-((6-氨基-6-氧代己基)氨基)-3-甲基-1-氧代戊烷-2-基)氨基)-3-(4-羟基苯基)-1-氧代丙烷-2-基)己酰胺 ;益智二肽 |
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英文名称 | Dihexa (Synonyms: PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2) |
CAS号 | 1401708-83-5 |
分子式 | C27H44N4O5 |
分子量 | 504.66 |
MDL | MFCD30533409 |
外观 | White to gray white powder |
储存条件 | Store at 0-4°C for short-term or -20°C for long-term in a dry, dark environment. |
Dihexa, an angiotensin IV analog, is a potent cognitive enhancer that crosses the BBB and binds to HGF with high affinity (Kd=65 pM), activating c-Met receptor pathways. It shows significant antidementia effects in animal models, suggesting therapeutic potential for Alzheimer's disease treatment.
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