中文名称 | 重组人白介素 15(rHuIL-15) |
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英文名称 | Recombinant Human Interleukin 15 (rHulL-15) |
储存条件 | Lyophilized samples are stable for 36 months from date of manufacture at -20℃ to -70℃. Upon reconstitution, this cytokine can be stored under sterile conditions at 2- 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles. |
Recombinant human IL-15 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 114 amino acids. It also contains 4 cysteine residues, forming 2 pairs of disulfide bonds in the chain.
IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells
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