中文名称 | 苦鬼臼毒素 |
---|---|
英文名称 | AXL1717 (Picropodophyllotoxin; Picropodophyllin; PPP) |
CAS号 | 477-47-4 |
分子式 | C₂₂H₂₂O₈ |
分子量 | 414.41 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR(FGF-R, PDGF-R, OR EGF-R). Picropodophyllin (PPP) induces apoptosis with antineoplastic activity.
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