高三尖杉酯碱
Homoharringtonine (Synonyms: CGX-635; Omacetaxine mepesuccinate; HHT; Myelostat; NSC 141633)
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产品库存
3-5 days
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¥406.00
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3-5 days
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¥668.00
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¥1088.00
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¥1766.00
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基本信息
中文名称高三尖杉酯碱
英文名称 Homoharringtonine (Synonyms: CGX-635; Omacetaxine mepesuccinate; HHT; Myelostat; NSC 141633)
CAS号26833-87-4
分子式C29H39NO9
分子量545.62
MDLMFCD05618221
外观Off-white to yellow powder
储存条件 4°C, protect from light
安全信息
产品详情

Homoharringtonine (Omacetaxine mepesuccinate; HHT) is a cytotoxic alkaloid derived from the Cephalotaxus tree, known for its significant antitumor properties. HHT acts primarily by inhibiting translation elongation, which disrupts protein synthesis crucial for cancer cell survival. This mechanism leads to the rapid degradation of several short-lived proteins, including Mcl-1 and c-Myc, triggering apoptosis in various cancer types, particularly in hematological malignancies such as acute myeloid leukemia (AML).
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