中文名称 | 哈尔碱; 哈尔明碱; 肉叶云香碱; 去氢骆驼蓬碱; 7-甲氧基-1-甲基-9H-吡啶并[3,4-b]吲哚 |
---|---|
英文名称 | Harmine(Banisterine);7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole; 7-Methoxy-1-methyl-9H-beta-carboline;7-methoxy-1-methyl-9H-pyrido[3,4-b]indole |
CAS号 | 442-51-3 |
分子式 | C13H12N2O |
分子量 | 212.25 |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Harmine (telepathine) is a naturally occuring beta-carboline and fluorescent harmala alkaloid found in a number of different plants, most notably the Middle Eastern plant harmal or Syrian rue (Peganum harmala) and the South American vine Banisteriopsis caapi (formerly known as 'yage' or 'ayahuasca'). Harmine is a RIMA because it reversibly inhibits the enzyme monoamine oxidase A (MAO-A), which breaks down monoamines. While it does not inhibit the MAO-B variant, harmine binds to MAO-A specifically. In addition, it is an inhibitor of tyrosine phosphorylation-regulated kinase (DYRK) with anti-inflammatory and anti-cancer properties. With a Ki of 397 nM, harmine exhibits a high affinity for the 5-HT2A serotonin receptor.
© 2020-2024 凯立德生物医药技术(上海)有限公司 版权所有
沪ICP备15046197号-3
沪公网安备31011502007856号
Designed by Kuanersoft