中文名称 | 茶黄素-3,3'-双没食子酸 |
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英文名称 | Theaflavin-3,3'-digallate | TF-3 | ZP10 | TFBG |
CAS号 | 33377-72-9 |
分子式 | C43H32O20 |
分子量 | 868.70 |
外观 | Brown to red powder |
储存条件 | -20°C, sealed storage, away from moisture and light |
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1. Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent.
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