酯蟾毒配基 | 蟾力苏 | 布福吉宁 | 脂蟾毒甙元
Resibufogenin | Bufogenin | Recibufogenin
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基本信息
中文名称酯蟾毒配基 | 蟾力苏 | 布福吉宁 | 脂蟾毒甙元
英文名称 Resibufogenin | Bufogenin | Recibufogenin
CAS号465-39-4
分子式C24H32O4
分子量384.51
外观White to off-white powder
储存条件Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1cyclin EPI3Kp-AKTp-GSK3β and β-catenin protein expression.

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