Chemleader Biomedical-Small Molecules 丨Intermediates 丨Drug Impurities

酯蟾毒配基 | 蟾力苏 | 布福吉宁 | 脂蟾毒甙元

Resibufogenin | Bufogenin | Recibufogenin

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产品编号：HL1716

CAS No.：465-39-4

MDLNo：

分子式：C24H32O4

分子量：384.51

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基本信息

中文名称	酯蟾毒配基 \| 蟾力苏 \| 布福吉宁 \| 脂蟾毒甙元
英文名称	Resibufogenin \| Bufogenin \| Recibufogenin
CAS号	465-39-4
分子式	C24H32O4
分子量	384.51
外观	White to off-white powder
储存条件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

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产品详情

Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.

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酯蟾毒配基 | 蟾力苏 | 布福吉宁 | 脂蟾毒甙元

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(2R,3R,4S,5S,6R)-2-(((3R,9S,10S,11S,13R,14S,17R)-11-羟基-17-((2R,5R)-6-羟基-6-甲基-5-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-((((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-2-基)氧基)庚-2-基)-4,4,9,13,14-五甲基-2,3,4,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊并[a]菲-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇;罗汉果苷 III；罗汉果甜苷 III；罗汉果甙 III；罗汉果甜甙 III

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