英文名称 | Brefeldin A(BFA) |
---|---|
中文名称 | 布雷菲德菌素A |
CAS号 | 20350-15-6 |
分子式 | C16H24O4 |
分子量 | 280.36 |
外观 | Off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名称 | Brefeldin A(BFA) |
---|---|
中文名称 | 布雷菲德菌素A |
CAS号 | 20350-15-6 |
分子式 | C16H24O4 |
分子量 | 280.36 |
外观 | Off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Brefeldin A (BFA) is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.