英文名称 | Tofacitinib (Tasocitinib; CP-690550) |
---|---|
中文名称 | 托法替尼;托法替布 |
CAS号 | 477600-75-2 |
分子式 | C16H20N6O |
分子量 | 312.37 |
外观 | White or off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名称 | Tofacitinib (Tasocitinib; CP-690550) |
---|---|
中文名称 | 托法替尼;托法替布 |
CAS号 | 477600-75-2 |
分子式 | C16H20N6O |
分子量 | 312.37 |
外观 | White or off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.