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维兰特罗三苯乙酸盐

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Vilanterol Trifenatate/Vilanterol Trifenate

产品编号:CL1181 CAS No.:503070-58-4 MDLNo: 分子式:C44H49Cl2NO7 分子量:774.77
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基本信息
英文名称 Vilanterol Trifenatate/Vilanterol Trifenate
中文名称维兰特罗三苯乙酸盐
CAS号503070-58-4
分子式C44H49Cl2NO7
分子量774.77
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
产品详情

 Vilanterol, also known as GW-642444, is a long-acting beta-2 agonist. It selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50s = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine. Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

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