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陶扎色替

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Tozasertib(VX-680;MK-0457)

产品编号：CL2144 CAS No.：639089-54-6 MDLNo： 分子式：C23H28N8OS 分子量：464.59

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规格	库存	目录价	会员专享价	数量
25 mg	3-5days	￥350.00	登录后可见	- +
50 mg	3-5days	￥550.00	登录后可见	- +
100 mg	3-5days	￥860.00	登录后可见	- +
500 mg	3-5days	￥2800.00	登录后可见	- +

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基本信息

英文名称	Tozasertib(VX-680;MK-0457)
中文名称	陶扎色替
CAS号	639089-54-6
分子式	C23H28N8OS
分子量	464.59
外观	White to off-white powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora A with K_i_app of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy.