英文名称 | ABT-888(Veliparib) |
---|---|
中文名称 | 维利帕尼 |
CAS号 | 912444-00-9 |
分子式 | C13H16N4O |
分子量 | 244.29 |
外观 | White solid |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名称 | ABT-888(Veliparib) |
---|---|
中文名称 | 维利帕尼 |
CAS号 | 912444-00-9 |
分子式 | C13H16N4O |
分子量 | 244.29 |
外观 | White solid |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Veliparib (ABT-888, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Veliparib increases autophagy and apoptosis. Phase 3.