Rebastinib (DCC-2036)

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规格

库存

目录价

会员专享价

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基本信息

英文名称	Rebastinib (DCC-2036)
中文名称	Rebastinib (DCC-2036)
CAS号	1020172-07-9
分子式	C30H28FN7O3
分子量	553.59
外观	White to off-white powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

Rebastinib (formerly also known as DCC-2036), a novel, potent and orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity, is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50s of 0.8 nM and 4 nM. It also inhibits other kinases such as SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and has low activity towards c-Kit. DCC-2036 inhibits ABL1 through forcing the kinase domains into inhibitor-bound, inactive Type II conformations. In cellular assay, DCC-2036 inhibits the proliferation of Ba/F3 and K562 cells with IC50 values of 5.4nM and 5.5nM, respectively.

Rebastinib (DCC-2036)

Rebastinib (DCC-2036)

化学品安全说明书(MSDS)