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噁拉戈利

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Elagolix (NBI-56418)

产品编号：CL2564 CAS No.：834153-87-6 MDLNo： 分子式：C32H30F5N3O5 分子量：631.59

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基本信息

英文名称	Elagolix (NBI-56418)
中文名称	噁拉戈利
CAS号	834153-87-6
分子式	C32H30F5N3O5
分子量	631.59
外观	White to off-white powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

产品详情

Elagolix (formerly NBI56418; ABT620; NBI-56418; ABT-620; trade name: Orilissa) is a potent, specific, orally bioavailable, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) used for pain management. It inhibits GnRHR with a Kd of 54 pM. Elagolix was given FDA approval on July 23, 2018, to treat endometriosis-related moderate to severe pain. A short-acting GnRH antagonist, elagolix suppresses ovarian estrogen production in a dose-dependent manner, resulting in partial suppression at lower doses and complete suppression at higher doses. Because Elagolix is non-peptide and readily absorbed through the mouth, it is considered the leader of a new class of GnRH inhibitors known as second-generation inhibitors.