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地红霉素

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Dirithromycin (LY-237216)

产品编号:CL2568 CAS No.:62013-04-1 MDLNo: 分子式:C42H78N2O14 分子量:835.07
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基本信息
英文名称 Dirithromycin (LY-237216)
中文名称地红霉素
CAS号62013-04-1
分子式C42H78N2O14
分子量835.07
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
产品详情

Dirithromycin (also known as LY-237216) is an Erythromycin derivative acting as a potent and orally bioactive semi-synthetic macrolide glycopeptide antibiotic, working by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides. Dirithromycin is a more lipid-soluble prodrug derivative of 9S-erythromycyclamine prepared by condensation of the latter with 2-(2-methoxyethoxy)acetaldehyde. The 9N, 11O-oxazine ring thus formed is a hemi-aminal that is unstable under both acidic and alkaline aqueous conditions and undergoes spontaneous hydrolysis to form erythromycyclamine.

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