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依那妥组单抗

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Enavatuzumab (Anti-TNFRSF12A / TWEAKR / CD266)

产品编号:CLA1263 CAS No.:1062149-33-0 MDLNo: 分子式: 分子量:
规格 库存 目录价 会员专享价 数量
1 mg 3-5days ¥4000.00 登录后可见
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5 mg 3-5days ¥16600.00 登录后可见
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10 mg 3-5days ¥28500.00 登录后可见
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50 mg 3-5days ¥127500.00 登录后可见
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基本信息
英文名称 Enavatuzumab (Anti-TNFRSF12A / TWEAKR / CD266)
中文名称依那妥组单抗
CAS号1062149-33-0
储存条件Store at 2 to 8 °C for 1-2 weeks. Store at -20 °C for 12 months. Store at -80 °C for long term storage. Use a manual defrost freezer and avoid repeated freeze-thaw cycles, away from light.
产品详情

Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK) . TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo.

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