(S)-(+)-Camptothecin; CPT

规格	库存	目录价	会员专享价	数量
1 g	In-stock	￥150.00	登录后可见	- +
5 g	3-5days	￥450.00	登录后可见	- +

基本信息

英文名称	(S)-(+)-Camptothecin; CPT
中文名称	(S)-(+)-喜树碱
CAS号	7689-03-4
分子式	C20H16N2O4
分子量	348.35
外观	Light yellow to yellow powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

安全信息

产品详情

DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs at the cleavage site, thus inhibiting religation, which activates apoptotic and cell cycle arrest pathways.Camptothecin is a cytotoxic, quinoline alkaloid, discovered as the active principle of extracts from the Chinese tree C. acuminate, that inhibits the DNA enzyme topoisomerase I (Top1). It binds the Top1-DNA cleavage complex, inducing DNA-strand breaks. Camptothecin has strong anti-tumor activity against a wide range of experimental tumors and inhibits both DNA and RNA synthesis in mammalian cells. It displays cytotoxity in HT-29 cells with an IC50 value of 10 nM and induces DNA damage at concentrations as low as 51 nM in whole cells and 12 nM in isolated nuclei in in vitro assays.

(S)-(+)-喜树碱

(S)-(+)-Camptothecin; CPT

化学品安全说明书(MSDS)

质检证书(COA)