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Home > Category > Signaling Pathways > DNA Damage/DNA Repair > Topoisomerase > Doxorubicin (Adriamycin) Hydrochloride (Synonyms: Doxorubicin (DOX) HCl; Hydroxydaunorubicin hydrochloride; ADR;NSC 123127;Hydroxydaunorubicin HCl )

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Catalog No：CL1004 CAS No.：25316-40-9 MDLNo：MFCD00077757 Formula：C27H29NO11.HCl MW： 579.98
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Product Overview
Product Name Doxorubicin (Adriamycin) Hydrochloride (Synonyms: Doxorubicin (DOX) HCl; Hydroxydaunorubicin hydrochloride; ADR;NSC 123127;Hydroxydaunorubicin HCl )
CAS25316-40-9
FormulaC27H29NO11.HCl
MW 579.98
MDLMFCD00077757
AppearanceOrange red powder
Storage conditionDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
Product details

Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.
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