RepSox|E-616452|E616452|E 616452|SJN 2511|SJN-2511|SJN2511

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	In-stock	￥488.00	Visible after login	- +
10 mg	In-stock	￥748.00	Visible after login	- +
25 mg	In-stock	￥1436.00	Visible after login	- +
50 mg	In-stock	￥2136.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

5 mg

In-stock

￥488.00

Visible after login

- +

10 mg

In-stock

￥748.00

Visible after login

- +

25 mg

In-stock

￥1436.00

Visible after login

- +

50 mg

In-stock

￥2136.00

Visible after login

- +

Product Overview

Product Name	RepSox (Synonyms: E-616452; SJN 2511;ALK5 Inhibitor II)
CAS	446859-33-2
Formula	C17H13N5
MW	287.32
MDL	MFCD09037561
Appearance	Light brown to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.
buy RepSox (E-616452) | RepSox (E-616452) supplier | purchase RepSox (E-616452) | RepSox (E-616452) cost | RepSox (E-616452) manufacturer | order RepSox (E-616452) | RepSox (E-616452) distributor

Related literature

Chemical reprogramming of human somatic cells to pluripotent stem cells.

PMID: 35418683 DOI: 10.1038/s41586-022-04593-5

TGFβR-1/ALK5 inhibitor RepSox induces enteric glia-to-neuron transition and influences gastrointestinal mobility in adult mice.

PMID: 35794374 PMCID: PMC9813375 DOI: 10.1038/s41401-022-00932-4

Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors.

PMID: 29742392 PMCID: PMC5995754 DOI: 10.1016/j.stemcr.2018.04.009

Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming.

PMID: 29937202 DOI: 10.1016/j.stem.2018.05.025

Sorry, no related items

History