Product Name | SB-431542 |
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CAS | 301836-41-9 |
Formula | C22H16N4O3 |
MW | 384.39 |
Appearance | white to off-white solid powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Size | Availability | Price(USD) | VIP Price (USD) | Quantity |
---|---|---|---|---|
10 mg | In-stock | ¥350.00 | Visible after login | |
20 mg | In-stock | ¥600.00 | Visible after login | |
50 mg | In-stock | ¥1150.00 | Visible after login |
Product Name | SB-431542 |
---|---|
CAS | 301836-41-9 |
Formula | C22H16N4O3 |
MW | 384.39 |
Appearance | white to off-white solid powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
SB-431542 is a novel small molecule inhibitor of the type I TGF-beta receptor, on a panel of human malignant glioma cell lines. SB-431542 blocked the phosphorylation and nuclear translocation of the SMADs, intracellular mediators of TGF-beta signaling, with decreased TGF-beta-mediated transcription. Furthermore, SB-431542 inhibited the expression of two critical effectors of TGF-beta-vascular endothelial growth factor and plasminogen activator inhibitor-1.