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Product Overview

Product Name	Ercalcitriol; 1α, 25-Dihydroxyvitamin D2
CAS	60133-18-8
Formula	C28H44O3
MW	428.65
Appearance	White to off-white powder
Storage condition	4°C, protect from light, stored under nitrogen

Product details

Ercalcitriol, also known as RO-17-6218 or 1,25-dihydroxyvitamin D2, is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney. By binding to the vitamin D receptor (VDR), 1,25-dihydroxy Vitamin D2 activates VDR to interact with the retinoid X receptor (RXR), forming the VDR/RXR/cofactor complex, which regulates gene transcription.

Related literature

A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta.

PMID: 2253400 DOI: 10.1016/0009-8981(90)90174-q

A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).

PMID: 2253400 DOI: 10.1016/0009-8981(90)90174-q

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History

CL1101

Ercalcitriol; 1α, 25-Dihydroxyvitamin D2

60133-18-8 98+%