Nedisertib | Peposertib | M3814 | MSC2490484A

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Product Overview

Product Name	Nedisertib (Synonyms: Peposertib; M3814; MSC2490484A)
CAS	1637542-33-6
Formula	C24H21ClFN5O3
MW	481.91
Appearance	Light yellow to yellow solid
Storage condition	-20℃, protect from light, stored under nitrogen

Product details

Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity.
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History

CL1302

Nedisertib (Synonyms: Peposertib; M3814; MSC2490484A)

1637542-33-6 98+%

(S)-[2-氯-4-氟-5-[7-(4-吗啉基)-4-喹唑啉基]苯基](6-甲氧基-3-哒嗪基)甲醇

Chemical safety data sheet(MSDS)