Home > Category > Signaling Pathways > Metabolism > FXR > Obeticholic Acid (Synonyms: INT-747; 6-ECDCA;6-Ethylchenodeoxycholic acid)

(R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-乙基-3,7-二羟基-10,13-二甲基十六氢-1H-环戊二烯并[a]菲-17-基)戊酸; 奥贝胆酸

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Catalog No:CL1437 CAS No.:459789-99-2 MDLNo:MFCD16621104 Formula:C26H44O4 MW:420.63
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Product Overview
Product Name Obeticholic Acid (Synonyms: INT-747; 6-ECDCA;6-Ethylchenodeoxycholic acid)
CAS459789-99-2
FormulaC26H44O4
MW420.63
MDLMFCD16621104
AppearanceWhite to off-white powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Product details

Obeticholic acid (OCA), a potent FXR agonist with an EC50 of 99 nM, targets bile acid synthesis and exhibits anticholeretic and anti-inflammatory effects, inducing autophagy. Its bioactivity is optimized through ROS-responsive nanoparticle delivery, enhancing liver targeting and reducing hepatotoxicity, offering a promising therapeutic strategy for cholestatic liver diseases.

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