Home > Category > Signaling Pathways > TGF-beta/Smad > TGF-β Receptors > Vactosertib (Synonyms: EW-7197; TEW-7197)

N-((4-([1,2,4]三唑[1,5-a]吡啶-6-基)-5-(6-甲基吡啶-2-基)-1H-咪唑-2-基)甲基)-2-氟苯胺

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Catalog No:CL1608 CAS No.:1352608-82-2 MDLNo: Formula:C22H18FN7 MW:399.42
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Product Overview
Product Name Vactosertib (Synonyms: EW-7197; TEW-7197)
CAS1352608-82-2
FormulaC22H18FN7
MW399.42
Product details

Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib has potently antimetastatic activity and anticancer effect.

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