| Product Name | Vactosertib (Synonyms: EW-7197; TEW-7197) |
|---|---|
| CAS | 1352608-82-2 |
| Formula | C22H18FN7 |
| MW | 399.42 |
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| Product Name | Vactosertib (Synonyms: EW-7197; TEW-7197) |
|---|---|
| CAS | 1352608-82-2 |
| Formula | C22H18FN7 |
| MW | 399.42 |
Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib has potently antimetastatic activity and anticancer effect.