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(S,E)-N-(4-((3-氯-4-氟苯基)氨基)-7-((四氢呋喃-3-基)氧基)喹唑啉-6-基)-4-(二甲基氨基)丁-2-烯酰胺

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Catalog No：CL1632 CAS No.：850140-72-6 MDLNo： MFCD12407405 Formula：C24H25ClFN5O3 MW：485.94

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
50 mg	In-stock	￥366.00	Visible after login	- +
100 mg	In-stock	￥568.00	Visible after login	- +
500 mg	In-stock	￥1886.00	Visible after login	- +
1 g	In-stock	￥2366.00	Visible after login	- +

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Product Overview

Product Name	Afatinib (Synonyms: BIBW 2992; 阿法替尼)
CAS	850140-72-6
Formula	C24H25ClFN5O3
MW	485.94
MDL	MFCD12407405
Appearance	White solid powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.

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